CD59, CD59 molecule (CD59 blood group), 966

N. diseases: 262; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 Biomarker disease GENOMICS_ENGLAND Early-onset chronic axonal neuropathy, strokes, and hemolysis: inherited CD59 deficiency. 25716358 2015
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 Biomarker disease GENOMICS_ENGLAND Targeted therapy with eculizumab for inherited CD59 deficiency. 24382084 2014
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 Biomarker disease GENOMICS_ENGLAND Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. 1382994 1992
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 Biomarker disease GENOMICS_ENGLAND CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. 23149847 2013
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria 		0.500 Biomarker disease GENOMICS_ENGLAND Early-onset chronic axonal neuropathy, strokes, and hemolysis: inherited CD59 deficiency. 25716358 2015
CUI: C4727002
Disease: Chronic Hemolysis
Chronic Hemolysis 		0.330 Biomarker disease GENOMICS_ENGLAND Early-onset chronic axonal neuropathy, strokes, and hemolysis: inherited CD59 deficiency. 25716358 2015
CUI: C0272242
Disease: Complement deficiency disease
Complement deficiency disease 		0.300 Biomarker group GENOMICS_ENGLAND Early-onset chronic axonal neuropathy, strokes, and hemolysis: inherited CD59 deficiency. 25716358 2015
CUI: C1148551
Disease: X-Linked Dyskeratosis Congenita
X-Linked Dyskeratosis Congenita 		0.300 Biomarker disease GENOMICS_ENGLAND Targeted therapy with eculizumab for inherited CD59 deficiency. 24382084 2014
CUI: C4755276
Disease: Primary CD59 deficiency
Primary CD59 deficiency 		0.300 Biomarker disease GENOMICS_ENGLAND Early-onset chronic axonal neuropathy, strokes, and hemolysis: inherited CD59 deficiency. 25716358 2015
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 GeneticVariation disease UNIPROT Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. 1382994 1992
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 GeneticVariation disease UNIPROT CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. 23149847 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.240 Biomarker disease RGD Loss of CD59 in the AMI lesions was observed in association with deposits of MAC from day one onward. 7515561 1994
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica 		0.240 ModifyingMutation disease RGD Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. 28212662 2017
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.210 Biomarker disease RGD Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy. 12453906 2002
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.200 Biomarker disease RGD Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model. 12909127 2003
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.200 Biomarker disease RGD To assess the role of CD59 in complement-mediated glomerular injury, 6D1 was tested in a model of experimental glomerulonephritis induced by a lectin and its antibodies. 7523753 1994
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases 		0.200 Biomarker group RGD Activation of complement components and reduced regulator expression in alcohol-induced liver injury in the rat. 12483994 2002
CUI: C0027720
Disease: Nephrosis
Nephrosis 		0.200 Biomarker disease RGD Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. 15843577 2005
CUI: C0027814
Disease: Neuritis, Autoimmune, Experimental
Neuritis, Autoimmune, Experimental 		0.200 Biomarker disease RGD The expression of CD59 in experimental allergic neuritis. 10450801 1999
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa. 10530491 1999
CUI: C0042165
Disease: Anterior uveitis
Anterior uveitis 		0.200 Biomarker disease RGD Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). 16751365 2006
CUI: C0267941
Disease: Pancreatitis, Acute Necrotizing
Pancreatitis, Acute Necrotizing 		0.200 ModifyingMutation disease RGD Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. 16425382 2005
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 GermlineCausalMutation disease ORPHANET CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. 23149847 2013
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria 		0.500 Biomarker disease HPO
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic 		0.120 Biomarker disease HPO